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FAP
FAP Overview
| English Name | Prolyl endopeptidase FAP | Approved Drugs | 0 |
| Drugs in Clinical Trials | 87 | Target Synonym | Post-Proline Cleaving Enzyme，FAPalpha，SIMP，Fibroblast Activation Protein， Alpha，Serine Integral Membrane Protease，Prolyl Endopeptidase FAP，EC 3.4.21.26，EC 3.4.14.5，EC 3.4.21.-，DPPIV，FAPA，170 kDa melanoma membrane-bound gelatinase，Seprase，Gelatine degradation protease FAP，Dipeptidyl peptidase FAP，Fibroblast activation protein alpha，APCE，Integral membrane serine protease，Surface-expressed protease，FAP |
| Highest Development Stage | Phase 3 Clinical | ||
| English Name | Prolyl endopeptidase FAP |
| Target Synonym | Post-Proline Cleaving Enzyme，FAPalpha，SIMP，Fibroblast Activation Protein， Alpha，Serine Integral Membrane Protease，Prolyl Endopeptidase FAP，EC 3.4.21.26，EC 3.4.14.5，EC 3.4.21.-，DPPIV，FAPA，170 kDa melanoma membrane-bound gelatinase，Seprase，Gelatine degradation protease FAP，Dipeptidyl peptidase FAP，Fibroblast activation protein alpha，APCE，Integral membrane serine protease，Surface-expressed protease，FAP |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 87 |
| Highest Development Stage | Phase 3 Clinical |
FAP Product List
- Product Category
Protein (15)Beads (1)Cell (1)Antibody (1)
- Product Status
Launched (17)In Research (1)
- Species
Human (9)Cynomolgus (3)Mouse (3)Rat (1)Canine (1)Rabbit (1)
- Tag
Fc Tag (2)His Tag (9)His Tag & Avi Tag (4)- (3)
- Conjugate
Unconjugated (6)FITC Labeled (4)Biotin-labeled (4)PE Labeled (1)- (2)AF647 Labeled (1)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
HOT FAP-H5244 |  Human | HEK293 | Human FAP Protein, His Tag, active dimer, low endotoxin (MALS verified) |  |  |  |
HOT FAP-H5263 | Human | HEK293 | Human FAP Protein, Fc Tag, active dimer, low endotoxin (MALS verified) |  | | |
HOT FAP-H82Q6 | Human | HEK293 | Biotinylated Human FAP Protein, His,Avitag™, active dimer (MALS verified) |  | | |
HOT FAP-M52H3 |  Mouse | HEK293 | Mouse FAP Protein, His Tag, active dimer (MALS verified) |  | | |
CHEK-ATP184 | Human | HEK293 | HEK293/Human FAP Stable Cell Line |  | ||
FAP-HA243 | Human | HEK293 | Alexa Fluor™ 647-Labeled Human FAP Protein, His Tag |  | | |
FAP-HF243 | Human | HEK293 | FITC-Labeled Human FAP Protein, His Tag |  | | |
FAP-HF263 | Human | HEK293 | FITC-Labeled Human FAP Protein, Fc Tag |  | | |
FAP-HP245 | Human | HEK293 | PE-Labeled Human FAP Protein, His Tag (Site-specific conjugation) |  | | |
MBS-K077 | Human | - | Human FAP-coupled Magnetic Beads |
Total: 18
- 1
- 2
FAP Synonyms
FAP,FAPalpha,SIMP,Seprase,APCE
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| 18F-LNC1007 | 18F-LNC1007; 18F-FAPI-RGD | Phase 3 Clinical | Yantai Lannacheng Biotechnology Co Ltd | Carcinoma, Renal Cell; Diagnostic agents; Neoplasms; Solid tumours | Details |
| [18F]FAPI-74 | Fluor-18-FAPI-74; F-18]FAPI-74; FAPI-74; [18F]FAPI-74 | Phase 3 Clinical | University Of Heidelberg | Adenocarcinoma; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Lobular; Carcinoma, Pancreatic Ductal; Cholangiocarcinoma; Colorectal Neoplasms; Dermatomyositis; Esophageal Neoplasms; Gastrointestinal Neoplasms; Mesothelioma; Ovarian Neoplasms; Pancreatic Neoplasms; Sarcoma; Stomach Neoplasms; Urinary Bladder Neoplasms | Details |
| [18F]fibronstatin | 18F-LNC1005; LNC-1005 | Phase 3 Clinical | Yantai Lannacheng Biotechnology Co Ltd | Diagnostic agents; Solid tumours; Stomach Neoplasms | Details |
| Talabostat | VbP; PT-100; BXCL-701 | Phase 2 Clinical | Point Therapeutics | Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Small Cell; CNS Embryonal Tumor; Kidney Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Liver Neoplasms; Lung Neoplasms; Melanoma; Myelodysplastic Syndromes; Neoplasm Metastasis; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroendocrine Tumors; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Sarcoma; Skin Neoplasms; Solid tumours | Details |
| MP-0317 | MP-0317 | Phase 2 Clinical | Molecular Partners Ag | Biliary Tract Neoplasms; Solid tumours | Details |
| GPN0-1530 | GPN01530; GPN0-1530 | Phase 2 Clinical | Grand Pharmaceutical （China） Co Ltd | Solid tumours | Details |
| 68Ga-FAP-RGD | 68Ga-FAP-RGD | Phase 2 Clinical | First Affiliated Hospital Of Fujian Medical University | Neoplasms | Details |
| 177Lu-D7ND | 177Lu-D7ND | Phase 2 Clinical | The First Affiliated Hospital of Xi'an Jiaotong University | Solid tumours | Details |
| [212Pb]Pb-PSV359 | [212Pb]Pb-PSV359 | Phase 2 Clinical | Perspective Therapeutics Inc | Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Esophageal Neoplasms; Head and Neck Neoplasms; Mesothelioma; Ovarian Neoplasms; Sarcoma; Stomach Neoplasms | Details |
| [203Pb]Pb-PSV359 | [203Pb]Pb-PSV359; [203Pb]-PSV359 | Phase 2 Clinical | Perspective Therapeutics Inc | Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Esophageal Neoplasms; Head and Neck Neoplasms; Mesothelioma; Ovarian Neoplasms; Sarcoma; Stomach Neoplasms | Details |
| 68Ga-NI-FAPI | 68Ga-NI-FAPI | Phase 2 Clinical | First Affiliated Hospital Of Fujian Medical University | Cardiomyopathy, Hypertrophic; Cardiovascular Diseases; Hypoxia; Immune System Diseases; Neoplasms; Pulmonary Fibrosis; Rheumatic Diseases | Details |
| HRS-6768 | HRS-6768; HRS6768 | Phase 2 Clinical | Tianjin Hengrui Pharmaceutical Co Ltd | Solid tumours | Details |
| 68Ga-TCR-FAPI | 68Ga-TCR-FAPI | Phase 2 Clinical | Tumor Research Institute Chinese Academy Of Medical Sciences | Medullary thyroid cancer (MTC); Neoplasms | Details |
| NTI-1309 | LNTH-1363S; NTI-1309; 64Cu-LNTH-1363S | Phase 2 Clinical | Noria Therapeutics Inc | Colorectal Neoplasms; Esophageal Neoplasms; Pancreatic Neoplasms; Sarcoma; Stomach Neoplasms | Details |
| AZD-2389 | AZD2389; AZD-2389 | Phase 2 Clinical | Astrazeneca Plc | Hepatic Insufficiency; Liver Cirrhosis; Liver Diseases | Details |
| AAA-614 | AAA-614; FAP-2286; Lu-FAP-2286 | Phase 2 Clinical | Novartis Ag | Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Solid tumours | Details |
| 68Ga-FAPI(Peking Union Medical College Hospital) | 68Ga-FAPI(Peking Union Medical College Hospital) | Phase 2 Clinical | Peking Union Medical College Hospital | Neoplasm Metastasis; Sjogren's Syndrome | Details |
| 177Lu-EB-FAPI | 177Lu-EB-FAPI | Phase 2 Clinical | Zhejiang University | Carcinoma, Pancreatic Ductal; Cholangiocarcinoma; Pancreatic Neoplasms | Details |
| 177Lu-DOTA-EB-FAPI | Phase 2 Clinical | The First Affiliated Hospital Of Xiamen University | Adenocarcinoma, Follicular; Oncocytic cell carcinoma of the thyroid; Solid tumours; Thyroid Cancer, Papillary; Thyroid Neoplasms | Details | |
| SHR-7367 | SHR7367; SHR-7367 | Phase 2 Clinical | Shanghai Hengrui Pharmaceutical Co Ltd | Neoplasms; Solid tumours | Details |
| 68Ga-FAP-2286 | 68Ga-FAP-2286; 68-Ga-FAP-2286 | Phase 2 Clinical | 3B Pharmaceuticals GmbH | Neoplasm Metastasis; Solid tumours | Details |
| 68Ga-FAPI-46 | [68Ga]FAPI-46; 68Ga-FAPI-46 | Phase 2 Clinical | Karolinska University Hospital | Adenomatous Polyposis Coli; Alveolitis, Extrinsic Allergic; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Ovarian Epithelial; Carcinoma, Pancreatic Ductal; Crohn Disease; Esophageal Neoplasms; Idiopathic Interstitial Pneumonias; Inflammatory Bowel Diseases; Intestinal Fibrosis; Lung Diseases, Interstitial; Melanoma; Metabolic Dysfunction-Associated Steatotic Liver Disease; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Pneumoconiosis; Pulmonary Fibrosis; Radiation Pneumonitis; Solid tumours; Stomach Neoplasms | Details |
| 177Lu-FAP-2286 | 177Lu-FAP-2286 | Phase 2 Clinical | 3B Pharmaceuticals GmbH | Neoplasms; Solid tumours | Details |
| NG-641 | EnAd-FAP-BiTE; EnAd-FAP-Tac; NG-641; NG-aFAP | Phase 1 Clinical | Akamis Bio Ltd | Neoplasm Metastasis; Neoplasms, Glandular and Epithelial; Squamous Cell Carcinoma of Head and Neck | Details |
| Simlukafusp alfa | FAP-IL2v; RG-7461; aFAP-IL2v; RO-6874281; FAP-IL2v FP | Phase 1 Clinical | F. Hoffmann-La Roche Ltd | Breast Neoplasms; Carcinoma, Renal Cell; Esophageal Neoplasms; Head and Neck Neoplasms; Melanoma; Solid tumours; Uterine Cervical Neoplasms | Details |
| 177Lu-DOTAGA.FAPi | TLX400; TLX-400; 177Lu-TLX400 | Phase 1 Clinical | Johannes Gutenberg University Of Mainz | Medullary thyroid cancer (MTC); Metastatic breast cancer; Urinary Bladder Neoplasms | Details |
| CD137/FAP bispecific agonist antibody (Boehringer Ingelheim International) | Phase 1 Clinical | Boehringer Ingelheim International Gmbh | Neoplasms | Details | |
| PSMA/NKG2DL/FAP-targeted Hi-TCR-T cells | Phase 1 Clinical | Shenzhen Misheng Biotechnology Co Ltd | Prostatic Neoplasms; Solid tumours | Details | |
| 68Ga-PNT-6555 | Phase 1 Clinical | Point Biopharma Inc | Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Esophageal Neoplasms; Melanoma; Sarcoma; Solid tumours | Details | |
| 68Ga-FAPI-XT-117 | Phase 1 Clinical | Beijing Xiantong International Technology Co Ltd | Solid tumours | Details | |
| OMTX-705 | OMTX-705 | Phase 1 Clinical | Oncomatryx Biopharma Sl | Adenocarcinoma; Solid tumours | Details |
| CAR-DC Targeting FAP therapy (Second Affiliated Hospital School Of Zhejiang University School Of Medicine) | Phase 1 Clinical | Second Affiliated Hospital School Of Zhejiang University School Of Medicine | Idiopathic Pulmonary Fibrosis; Shock, Cardiogenic; ST Elevation Myocardial Infarction | Details | |
| CD40xFAP bispecific antibody (Bristol-Myers Squibb Company) | Phase 1 Clinical | Bristol-Myers Squibb Company | Solid tumours | Details | |
| 177Lu-JH040182 | 177Lu-JH040182; 177LuJH040182; [177Lu]-JH04 | Phase 1 Clinical | Bivision Biomedical Technology (Shanghai) Co Ltd | Solid tumours | Details |
| 177Lu-BRP-010030 | 177LuBRP010030; 177Lu-BRP-010030 | Phase 1 Clinical | BoomRay Pharmaceuticals Co Ltd | Solid tumours | Details |
| LY-4337713 | LY4337713; LY-4337713 | Phase 1 Clinical | Eli Lilly And Company | Breast Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Esophageal Neoplasms; Ovarian Neoplasms; Pancreatic Intraductal Neoplasms; Stomach Neoplasms | Details |
| MP-0310 | MP-0310; AMG-506 | Phase 1 Clinical | Amgen Inc, Molecular Partners Ag | Solid tumours | Details |
| 68Ga-FAPI-GP | Phase 1 Clinical | Affiliated Hospital of Guilin Medical University | Solid tumours | Details | |
| 177Lu-FAPI-FUSCC | Phase 1 Clinical | Fudan University Shanghai Cancer Center | Solid tumours | Details | |
| 225Ac-FAPI-XT | XT117 | Phase 1 Clinical | Cancer Hospital of Shandong First Medical University | Solid tumours | Details |
| 68Ga-DOTA-FAPI-04 | 68Ga-DOTA-FAPI-04 | Phase 1 Clinical | The First Affiliated Hospital Of Xiamen University | Neuroendocrine Tumors | Details |
| 68Ga-GP-01 | 68Ga-GP-01 | Phase 1 Clinical | Chengdu Shetai Medical Technology Co Ltd | Solid tumours | Details |
| 177Lu-NRT6020 | 177Lu-NRT6020 | Phase 1 Clinical | Chengdu New Radiomedicinetechnology Co Ltd | Solid tumours | Details |
| 68Ga-NRT6020 | 68Ga-NRT6020 | Phase 1 Clinical | Chengdu New Radiomedicinetechnology Co Ltd | Solid tumours | Details |
| 3BP-4961 | 3BP-4961; SPECTROFAP; 99mTc-3BP-4961 | Phase 1 Clinical | 3B Pharmaceuticals GmbH | Neoplasms | Details |
| AVA-6103 | AVA6103; AVA-6103 | Phase 1 Clinical | Avacta Group PLC | Adenocarcinoma; Carcinoma, Pancreatic Ductal; Esophageal Neoplasms; Neoplasms; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Stomach Neoplasms; Uterine Cervical Neoplasms | Details |
| [177Lu]Lu-OncoFAP-23 | [177Lu]Lu-OncoFAP-23 | Phase 1 Clinical | Philogen Spa | Adenomatous Polyposis Coli | Details |
| 177Lu-FAPI-RGD | 177Lu-FAPI-RGD; [177Lu]-FAPI-RGD | Phase 1 Clinical | Peking Union Medical College Hospital | Neoplasms | Details |
| 177Lu-JH04 | 177Lu-JH04 | Phase 1 Clinical | First Affiliated Hospital Of Fujian Medical University | Neoplasms | Details |
| [68Ga]Ga-NNS309 | [68Ga]Ga-NNS309 | Phase 1 Clinical | Novartis Pharma Ag | Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Triple Negative Breast Neoplasms | Details |
| [177Lu]Lu-NNS309 | [177Lu]Lu-NNS309; FXX489; FXX-489 | Phase 1 Clinical | Novartis Pharma Ag | Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Large intestine neoplasm; Triple Negative Breast Neoplasms | Details |
| Lutetium [177Lu]-FAP-75 | Lutetium [177Lu]-FAP-75 | Phase 1 Clinical | Fudan University | Solid tumours | Details |
| 68Ga-JH04 | 68Ga-JH04; JH-04 | Phase 1 Clinical | Bivision Pharmaceuticals Inc | Neoplasms | Details |
| 68Ga-DOTA-NI-FAPI04 | 68Ga-DOTA-NI-FAPI04 | Phase 1 Clinical | First Affiliated Hospital Of Fujian Medical University | Neoplasms | Details |
| 68Ga-FAPI-JH04 | 68Ga-FAPI-JH04 | Phase 1 Clinical | First Affiliated Hospital Of Fujian Medical University | Neoplasms | Details |
| 68Ga-PSFA | 68Ga-PSFA | Phase 1 Clinical | First Affiliated Hospital Of Chongqing Medical University | Adenomatous Polyposis Coli | Details |
| 68 Ga-OncoFAP-DOTAGA | 68 Ga-OncoFAP | Phase 1 Clinical | Blue Earth Diagnostics, Philochem | Solid tumours | Details |
| 18F-AlF-FAPi-04 | 18F-AlF-FAPi-04 | Phase 1 Clinical | Affiliated Hospital Of North Sichuan Medical College | Solid tumours | Details |
| 177Lu-EB-FAPI(Peking Union Medical College Hospital) | 177Lu-EB-FAPI(Peking Union Medical College Hospital) | Phase 1 Clinical | Peking Union Medical College Hospital | Neoplasm Metastasis | Details |
| [64Cu]Cu-XT117 | [64Cu]Cu-XT117; 64Cu-FAPI-XT117 | Phase 1 Clinical | Beijing Xiantong International Technology Co Ltd | Solid tumours | Details |
| [177Lu]Lu-XT117 | XTR-017; XTR017; [177Lu]Lu-XT117 | Phase 1 Clinical | Beijing Xiantong International Technology Co Ltd | Solid tumours | Details |
| RTX-1363-S | RTX-1363S; RTX-1363-S | Phase 1 Clinical | Ratio Therapeutics Inc | Breast Neoplasms; Lung Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms | Details |
| 68Ga/64Cu-FAPI-XT117 | 68Ga/64Cu-FAPI-XT117 | Phase 1 Clinical | Beijing Xiantong International Technology Co Ltd | Solid tumours | Details |
| 177Lu-LNC1004 | 177Lu-LNC1004; 177Lu-LNC-1004 | Phase 1 Clinical | Yantai Lannacheng Biotechnology Co Ltd | Solid tumours | Details |
| 68Ga-LNC-1007 | 68Ga-FAPI-RGD; 68Ga-LNC-1007 | Phase 1 Clinical | Yantai Lannacheng Biotechnology Co Ltd | Carcinoma, Renal Cell; Neoplasms | Details |
| BI-765179 | BI-765179 | Phase 1 Clinical | Boehringer Ingelheim International Gmbh | Neoplasms; Squamous Cell Carcinoma of Head and Neck | Details |
| RO-7300490 | RO-7300490; RG-6189; FAP-CD40; FAP-huCD40 | Phase 1 Clinical | F. Hoffmann-La Roche Ltd | Solid tumours | Details |
| 177Lu-DOTA-FAPI | 177Lu-DOTA-2P | Phase 1 Clinical | The First Affiliated Hospital Of Xiamen University | Neoplasm Metastasis; Solid tumours | Details |
| RO-7122290 | RO-7122290; RG-7827 | Phase 1 Clinical | F. Hoffmann-La Roche Ltd | Colorectal Neoplasms | Details |
| anti-BCMA/NKG2DL/FAP TCR T-cell therapy (Guangdong VitaLife) | Clinical | Guangdong Vitalife Biotechnology Co Ltd | Multiple Myeloma | Details | |
| 68Ga-FAPI(Meander Medical Center) | 68Ga-FAPI | Clinical | Meander Medical Center | Carcinoma, Non-Small-Cell Lung | Details |
| 68Ga-BR-54 | 68Ga-BR-54 | Clinical | BoomRay Pharmaceuticals Co Ltd | Neoplasms | Details |
| 68Ga-DOTA-GPFAPI-04 | [68Ga]Ga-DOTA-GPFAPI-04; 68Ga-GPFAPI-04 | Clinical | Guangdong Provincial People'S Hospital, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Neoplasm Metastasis; Neoplasms | Details |
| 90Y-FAPI-04 | Clinical | Heidelberg University Hospital | Breast Neoplasms | Details | |
| 68Ga-NOTA-FAPI04 | Clinical | Beijing Cancer Hospital | Lymphoma | Details | |
| 68Ga-DOTA-FAPI-46 | Clinical | The First Affiliated Hospital Of Xiamen University | Neoplasms | Details | |
| 68Ga-DOTA-2P(FAPI)2 | Clinical | The First Affiliated Hospital Of Xiamen University | Neoplasms | Details | |
| [18F]AlF-NOTA-FAPI-04 | Clinical | Sichuan Provincial People'S Hospital | Kidney Diseases | Details | |
| 99mTc-HFAPI | Clinical | Peking Union Medical College Hospital | Pulmonary Fibrosis | Details | |
| 68Ga/18F-FAPI-04 | Clinical | Nanjing First Hospital, Nanjing Medical University | Endomyocardial Fibrosis | Details | |
| 68Ga-FAPI-LM3 | 68Ga-FAPI-LM3 | Clinical | The First Affiliated Hospital Of Xiamen University | Adenomatous Polyposis Coli | Details |
| [18F]AlF-FAPI-74 | 18F-AlF-FAPI-74; [18F]-ALF-FAPI-74 | Clinical | Umc Utrecht | Colorectal Neoplasms | Details |
| XTR-016 | XTR-016; XTR016 | Clinical | Beijing Xiantong International Technology Co Ltd | Solid tumours | Details |
| 177Lu-BRP-010 | BRP-010; 177Lu-BRP-010 | Clinical | BoomRay Pharmaceuticals Co Ltd | Solid tumours | Details |
| 68Ga-BRP-010 | BRP-010; 68Ga-BRP-010 | Clinical | BoomRay Pharmaceuticals Co Ltd | Solid tumours | Details |
| [90Y] YFAPI-46 | Clinical | German Cancer Consortium (Dktk), University of Duisburg-Essen | Solid tumours | Details | |
| 3BP-3940 | 3BP-3940 | Clinical | 3B Pharmaceuticals GmbH, Johannes Gutenberg University Of Mainz | Neoplasms | Details |
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